PERFORM IN DEPTH MOLECULAR CHARACTERIZATION OF CLINICAL SAMPLES TO THE SINGLE CELL LEVEL AND ASSESS THE EFFECTS OF TREATMENT ON CELLULAR AND MOLECULAR HETEROGENEITY BEFORE AND DURING TREATMENT.

PIs: Paul Mischel, M.D.
Professor, Pathology and Laboratory Medicine
University of California Los Angeles (UCLA) School of Medicine

Timothy Cloughesy, M.D.
Director, Neuro-Oncology Program
University of California Los Angeles (UCLA) School of Medicine

James R. Heath, Ph.D.
Elizabeth W. Gilloon Professor
California Institute of Technology

Award: $2,250,000 over three years

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DEVELOPMENT OF A NEURO-ONCOLOGY IMAGING PROGRAM USING MRI-PET AND MOLECULAR PROBES FOR IMPROVING THE MANAGEMENT OF GLIOMA.

PI: Sanjiv Sam Gambhir, M.D., Ph.D.
Head of Radiology and Nuclear Medicine Program
Stanford University

Award: $10,000,000 over five years

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OUTLIERS IN GLIOBLASTOMA OUTCOME. DEEP GENOMIC ANALYSIS OF SHORT-TERM AND LONG-TERM SURVIVORS OF GBM TO UNDERSTAND THE MOLECULAR BASIS OF RESPONSE TO THERAPY AND TO GUIDE NEW TREATMENT DEVELOPMENT.

PI: Jeffrey M. Trent, Ph.D.
President and Scientific Director
Translational Genomics Research Institute (TGen)

Award: $5,000,000 over five years