Research Funded To Date

AN INTEGRATED APPROACH UTILIZING LARGE-SCALE CHEMICAL SCREENS TO IDENTIFY THERAPEUTIC AGENTS AGAINST TUMOR INITIATING CELLS DERIVED FROM INDIVIDUAL PATIENTS. CANDIDATES ARE EVALUATED IN VIVO IN MATCHING PATIENT-DERIVED XENOGRAFT MODELS TO ALLOW PATIENT-SPECIFIC THERAPEUTIC AGENTS.

PI: Greg D. Foltz, M.D.
Director, The Ben & Catherine Ivy Center for Advanced Brain Tumor Treatment
Swedish Medical Center

Award: $2,500,000 over five years


A COLLABORATIVE EFFORT BETWEEN TRANSLATIONAL GENOMICS RESEARCH INSTITUTE AND THE IVY EARLY PHASE CLINICAL TRIALS CONSORTIUM (UCSF, UCLA, MSKCC, MGH, DFCC, MD Anderson, Un. of Utah) TO DEVELOP INNOVATIVE CLINICAL TRIALS FOR GBM PATIENTS WHICH WILL MATCH AN INDIVIDUAL’S MOLECULAR PATHOLOGY TO TARGETED THERAPIES, INCLUDING ALIGNING GENOMIC INFORMATION, GLIOMA BIOLOGY, PRECISION GUIDED DELIVERY AND ACCESS TO NEW AGENTS.

PIs: John Carpten, Ph.D.
Deputy Director of Basic Science
Translational Genomics Research Institute (TGen)

David Craig, Ph.D.
Deputy Director of Bioinformatics
Translational Genomics Research Institute (TGen)

Award: $5,000,000 over five years


IVY NEUROLOGICAL SCIENCES INTERNSHIP PROGRAM AT TGEN DESIGNED TO GIVE HIGH SCHOOL AND UNDERGRADUATE STUDENTS INTENSIVE, HANDS-ON RESEARCH EXPERIENCE WORKING ALONGSIDE A MENTOR-SCIENTIST TO LEARN ABOUT TRANSLATIONAL RESEARCH WHILE INVESTIGATING QUESTIONS WITHIN THE NEUROLOGICAL SCIENCES.

PI: Brandy Wells
Director, Public Affairs and Education
Translational Genomics Research Institute (TGen)

Award:  $77,880