Research Funded To Date

INVESTIGATION OF THE SAFETY AND EFFICACY OF USING TARGETED RADIOTHERAPY TO ELIMINATE A HUMAN NEURAL STEM CELL NICHE THAT IS CO-OPTED BY GLIOBLASTOMA CELLS IN NEWLY-DIAGNOSED PATIENTS.

PI: Nader Sanai, M.D.
Director, Division of Neurosurgical Oncology
Director, Barrow Brain Tumor Research Center
Barrow Neurological Institute

Award:  $885,294 over four years


THE ADDITIONAL FUNDING FOR THE MAYO CLINIC PROGRAM IN DENDRITIC CELL VACCINES FOR NEWLY DIAGNOSED GLIOBLASTOMAS WILL EXPAND THE NUMBER OF PATIENTS TO PROVIDE STRONG STATISTICAL CONFIRMATION OF RESULTS AS WELL AS INCLUDE PATIENTS WITH RELAPSED GLIOBLASTOMA TO THE STUDY.

PI:  Allan B. Dietz, Ph.D.
Scientific Director, Human Cell Therapy Lab
Mayo Clinic

Award:  $1,971,612 over five years


EXTENSION INTO YEAR 6 OF THE ORIGINAL 2009 AWARD FOR PROJECT TITLED “IVY FOUNDATION EARLY PHASE CLINICAL TRIALS CONSORTIUM” TO INCREASE THE EFFICIENCY AND SUCCESS OF THERAPEUTIC TRIALS.

PI:  Michael D. Prados, M.D.
Charles B. Wilson Professor of Neurosurgergery
Professor of Pediatrics (Neuro-Oncology)
Program Leader, Neurological Oncology Program, UCSF Helen Diller Cancer Center
Project Leader, Ivy Foundation Early Phase Clinical Trials Consortium
Project Leader, Pacific Pediatric Neuro-Oncology Consortium
University of California San Francisco (UCSF)

Award:  $881,548 over one year


CREATION OF A RADIOGENOMICS PROJECT THAT WILL REPRESENT THE LARGEST SYSTEMATIC CORRELATION OF PRE/POST-OP IMAGING FEATURES WITH SPECIFIC GENOMIC MUTATIONS AND CLINICAL OUTCOME IN GLIOBLASTOMA.

PI: Michael D. Prados, M.D.
Charles B. Wilson Professor of Neurosurgergery
Professor of Pediatrics (Neuro-Oncology)
Program Leader, Neurological Oncology Program, UCSF Helen Diller Cancer Center
Project Leader, Ivy Foundation Early Phase Clinical Trials Consortium
Project Leader, Pacific Pediatric Neuro-Oncology Consortium
University of California San Francisco (UCSF)

Award:  $297,000 over one year


IMAGING PHENOTYPES IN NEWLY DIAGNOSED GLIOBLASTOMA PROJECT TO EMPLOY THE UNIQUE IMAGING ARCHIVE THAT HAS BEEN COLLECTED BY MEMBERS OF THE IVY CONSORTIUM IN ORDER TO LINK PREVIOUSLY IDENTIFIED IMAGING METRICS TO OUTCOME (PROGRESSION-FREE AND OVERALL SURVIVAL) AND TO EXPLORE THE RELATIONSHIPS BETWEEN IN VIVO PARAMETERS AND MOLECULAR PROPERTIES OF CORRESPONDING TISSUE SAMPLES FROM THE VIRTUAL TUMOR BANK.

PI: Michael D. Prados, M.D.
Charles B. Wilson Professor of Neurosurgergery
Professor of Pediatrics (Neuro-Oncology)
Program Leader, Neurological Oncology Program, UCSF Helen Diller Cancer Center
Project Leader, Ivy Foundation Early Phase Clinical Trials Consortium
Project Leader, Pacific Pediatric Neuro-Oncology Consortium
University of California San Francisco (UCSF)

Award:  $231,000 over one year


NEUROLOGICAL SCIENCES INTERNSHIP PROGRAM AT TGEN DESIGNED TO GIVE HIGH SCHOOL AND UNDERGRADUATE STUDENTS INTENSIVE, HANDS-ON RESEARCH EXPERIENCE WORKING ALONGSIDE A MENTOR-SCIENTIST TO LEARN ABOUT TRANSLATIONAL RESEARCH WHILE INVESTIGATING QUESTIONS WITHIN THE NEUROLOGICAL SCIENCES.

PI: Brandy Wells
Director, Public Affairs and Education
Translational Genomics Research Institute (TGen)

Award:  $91,824