ENHANCING CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL THERAPY FOR GLIOBLASTOMA THROUGH THE INDUCTION OF IFN-SIGNALING PATHWAYS. THIS APPROACH AIMS TO ADDRESS TWO OF THE MAJOR CHALLENGES OF IMMUNOTHERAPIES FOR GBM, THE IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT (TME) AND THE TUMOR HETEROGENEITY.

PIs: Darya Alizadeh, Ph.D.
Assistant Research Professor in the Department of Hematology/Hematopoietic Cell Transplantation (HCT)
City of Hope

Christine Brown, Ph.D.
Associate Director, T Cell Therapeutics Research Laboratory
Departments of Hematology and Hematopoietic Cell Transplantation and Immuno-Oncology
City of Hope

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