Research Funded To Date
The Ben and Catherine Ivy Foundation is dedicated to finding a cure for brain cancer. We strive in improve the quality of life and increase the life expectancy of those diagnosed with brain cancer by funding promising research that creates more diagnostics and treatments for patients.
Since 2008, we have funded 36 separate institutions with over 114 different research grants totaling over $165 million. These grants have involved research in phase 0 clinical trials, biomarkers, genomics, imaging, immunotherapy, stem cell, vaccines, and the development of possible new drugs.
2008
EVALUATION OF TB006 FOR TREATMENT OF GLIOBLASTOMA
PI: Nicholas Butowski, MD
Director of Translational Research in Neuro-oncology
University of California, San Francisco
David Raleigh, M.D., Ph.D.
Assistant Professor
University of California, San Francisco
Rada Savic, Ph.D.
Professor
University of California, San Francisco
Eunsol Yang, PharmD., Ph.D.
Postdoctoral Scholar
University of California, San Francisco
TESTING OF SMALL MOLECULE AND IMMUNO-ONCOLOGY DRUGS IN PERSONALIZED GLIOBLASTOMA EX VIVO ECOSYSTEM. DRUGS IN PRECLINICAL DEVELOPMENT FOR TREATING GLIOBLASTOMA
PI: Ralph B. Puchalski, PhD
Clinical Research Scientist
Swedish Health Services
RNA THERAPEUTICS FOR GLIOBLASTOMA: SMALL MOLECULES TARGETING ONCOGENIC MIR-10B-SIGNALING
PI: George A. Calin, M.D., Ph.D
Professor
The University of Texas MD Anderson Cancer Center
Frederik Lang, MD
Chairman, Department of Neurosurgery
Award: $600,000 over two yearsThe University of Texas MD Anderson Cancer Center
DEVELOP A PROTAC-BASED THERAPY FOR GLIOBLASTOMA
PI: Christian E. Badr, Ph.D.
Associate Professor in Neurology
Massachusetts General Hospital
Ralph Mazitschek, Ph.D.
Assistant Professor
Massachusetts General Hospital
PROVIDE A NEW THERAPEUTIC STRATEGY USING OUR FIRST IN-CLASS DRUG TO REMODEL CHROMATIN TO FORCE GLIOMA STEM CELLS TO DIFFERENTIATE, THEREBY IMPROVING GLIOBLASTOMA CONTROL
Jennifer Yu, M.D., Ph.D.
Department of Cancer Biology and Department of Radiation Oncology
Cleveland Clinic
Liangqi Xie, PhD
Assistant Staff
Cleveland Clinic
Yogen Saunthararajah, MD
Professor
Cleveland Clinic
DESIGN OPTIMIZATION OF A NEXT GENERATION T CELL IMMUOTHERAPY FOR GLIOBLASTOMA EMPLOYING A CHIMERIC ANTIGEN RECEPTOR (CAR) INCORPORATING CHLOROTOXIN (CLTX) AS A TUMOR RECOGNITION DOMAIN
PI: Christine E. Brown, Ph.D.
Professor of Immunotherapy
City of Hope
Michael E. Barish, Ph.D.
Professor, Department of Stem Cell Biology and Regenerative Medicine
City of Hope
TARGETING DDX3, A PREDICTIVE BIOMARKER FOR EFFECTIVE RADIOSENSITIZING TREATMENT OF GLIOBLASTOMA IN COMBINATION WITH RADIATION
PI: Venu Ramen, Ph.D.
Professor of Radiology, Oncology, and Pharmacology
Johns Hopkins University
David Olayinka Kamson, M.D., Ph.D.
Assistant Professor of Oncology and Neurology
Johns Hopkins University
Betty Tyler, B.A.
Associate Professor in Neurosurgery
Johns Hopkins University
A MULTIANALYTE PLATFORM FOR EVALUATING RESPONSE TO TARGETED THERAPY IN BRAF-ALTERED GLIOMAS
PI: Karisa Schreck, M.D., Ph.D.
Assistant Professor of Neurology and Oncology
Johns Hopkins University
Chetan Bettegowda, M.D., Ph.D.
Professor of Neurosurgery and Oncology
Johns Hopkins University
Peng Huang, Ph.D.
Associate Professor of Oncology
Johns Hopkins University
USE OF ARTIFICIAL INTELLIGENCE TO ANALYZE PATIENT TUMOR SAMPLES FOR DEVELOPING PERSONALIZED AND EFFECTIVE GLIOMA TREATMENTS
PI: Tara Gujral, PhD
Associate Professor
Fred Hutchinson Cancer Center
Eric C. Holland, M.D., Ph.D.
Senior VP
Fred Hutchinson Cancer Center
Jing Wu, M.D., Ph.D.
Investigator and Attending Neuro-Oncologist
National Cancer Institute
NEUROLOGICAL SCIENCES INTERNSHIP PROGRAM AT TGEN DESIGNED TO GIVE HIGH SCHOOL AND UNDERGRADUATE STUDENTS INTENSIVE, HANDS-ON RESEARCH EXPERIENCE WORKING ALONGSIDE A MENTOR-SCIENTIST TO LEARN ABOUT TRANSLATIONAL RESEARCH WHILE INVESTIGATING QIESTIONS WITHIN THE NEUROLOGICAL SCIENCES
PI: Kristen Kaus
Manager of Education and Outreach
Translational Genomics Research Institute (TGEN)